成果/Result
- Mechanistic insight into the disruption of Tau R3-R4 protofibrils by curcumin and epinephrine: an all-atom molecular dynamics study被引量：24收藏
- 作者：Zou, Yu Qi, Bote Tan, Jingwang Sun, Yunxiang Gong, Yehong Zhang, Qingwen
- 机构：Zhejiang Univ;Fudan Univ;Fudan Univ;Ningbo Univ;East China Univ Sci & Technol
- 来源：PHYSICAL CHEMISTRY CHEMICAL PHYSICS 2022
- 关键词：Aggregates - Binding energy - Hydrogen bonds - Hydrophobicity - Molecules - Positive ions
- The destructive mechanism of Aβ1-42 protofibrils by norepinephrine revealed via molecular dynamics simulations被引量：15收藏
- 作者：Gao, Duo Wan, Jiaqian Zou, Yu Gong, Yehong Dong, Xuewei Xu, Zhengdong Tang, Jiaxing Wei, Guanghong Zhang, Qingwen
- 机构：Shanghai Univ Sport;Zhejiang Univ;East China Univ Sci & Technol;Fudan Univ;Fudan Univ
- 来源：PHYSICAL CHEMISTRY CHEMICAL PHYSICS 2022
- 关键词：Medical imaging - Molecular dynamics - Neurodegenerative diseases - Norepinephrine - Protonation
- Dissecting the Inhibitory Mechanism of the αB-Crystallin Domain against Aβ42 Aggregation and Its Effect on Aβ42 Protofibrils: A Molecular Dynamics Simulation Study被引量：13收藏
- 作者：Xu, Zhengdong Gong, Yehong Zou, Yu Wan, Jiaqian Tang, Jiaxing Zhan, Chendi Wei, Guanghong Zhang, Qingwen
- 机构：Shanghai Univ Sport;East China Univ Sci & Technol;Zhejiang Univ;Fudan Univ;Fudan Univ
- 来源：ACS CHEMICAL NEUROSCIENCE 2022
- 关键词：amyloid-? aB-crystallin HSPB5 molecular dynamics simulation Alzheimer?s disease inhibitory mechanism
- Molecular Mechanism in the Disruption of Chronic Traumatic Encephalopathy-Related R3-R4 Tau Protofibril by Quercetin and Gallic Acid: Similarities and Differences被引量：13收藏
- 作者：Tang, Jiaxing Zou, Yu Gong, Yehong Xu, Zhengdong Wan, Jiaqian Wei, Guanghong Zhang, Qingwen
- 机构：Shanghai Univ Sport;Zhejiang Univ;East China Univ Sci & Technol;Fudan Univ;Fudan Univ
- 来源：ACS CHEMICAL NEUROSCIENCE 2023
- 关键词：chronic traumatic encephalopathy contact sports tau protein quercetin gallic acid molecular dynamics simulation
- Inhibitive and destructive Mechanisms of Chronic Traumatic Encephalopathy-Related R3-R4 Tau Peptide Chains and Protofibril by Epigallocatechin Gallate: Evidence from Molecular Dynamics Simulation被引量：9收藏
- 作者：Tang, Jiaxing Sun, Ruiqing Wan, Jiaqian Xu, Zhengdong Gong, Yehong Zou, Yu Zhang, Qingwen
- 机构：Shanghai Univ Sport;East China Univ Sci & Technol;Zhejiang Univ
- 来源：ACS CHEMICAL NEUROSCIENCE 2023
- 关键词：chronic traumatic encephalopathy tau protein collision or contact sports EGCG molecularmechanism molecular dynamics simulation
- destabilization mechanism of R3-R4 tau protofilament by purpurin: a molecular dynamics study被引量：3收藏
- 作者：Wan, Jiaqian Zou, Yu Sun, Ruiqing Xu, Zhengdong Tang, Jiaxing Gong, Yehong Wei, Guanghong Zhang, Qingwen
- 机构：Shanghai Univ Sport;Zhejiang Univ;East China Univ Sci & Technol;Fudan Univ;Fudan Univ
- 来源：PHYSICAL CHEMISTRY CHEMICAL PHYSICS 2023
- 关键词：Aggregates - Ketones - Neurodegenerative diseases
- 运动干预阿尔茨海默病患者认知功能元分析文献的方法学与证据质量评价被引量：2收藏
- 作者：许正东 弓烨弘 万嘉倩 李鹏辉 张庆文
- 机构：上海体育学院体育教育训练学院;华东理工大学体育科学与工程学院;上海震旦职业学院教育学院
- 来源：《上海体育学院学报》 2022
- 关键词：运动 阿尔茨海默病 认知功能 元分析 AMSTAR2 GRAde
- 摘要：目的评估运动对阿尔茨海默病(Alzheimer's Disease,AD)患者认知功能干预效果元分析文献的方法学质量及其结局指标的证据质量,并提出相应建议。方法通过PubMed、Scopus和中国知网等数据库,搜集运动干...
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