成果/Result
- Identification of novel thermostable taurine-pyruvate transaminase from Geobacillus thermodenitrificans for chiral amine synthesis被引量：30收藏
- 作者：Chen, Yujie Yi, Dong Jiang, Shuiqin Wei, Dongzhi
- 机构：E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2016
- 关键词：Taurine-pyruvate transaminase omega-Transaminase Biocatalysis Thermostable transaminase Chiral amine
- Switching a nitrilase from Syechocystis sp PCC6803 to a nitrile hydratase by rationally regulating reaction pathways被引量：27收藏
- 作者：Jiang, Shuiqin Zhang, Lujia Yao, Zhiqiang Gao, Bei Wang, Hualei Mao, Xiangzhao Wei, Dongzhi
- 机构：East China Univ Sci & Technol;Ocean Univ China
- 来源：CATALYSIS SCIENCE & TECHNOLOGY 2017
- 关键词：Amides - Biochemical engineering - Enzymes
- Recent research advancements on regioselective nitrilase: fundamental and applicative aspects被引量：19收藏
- 作者：Chen, Zhi Zhao, Jiang Jiang, Shuiqing Wei, Dongzhi
- 机构：East China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2019
- 关键词：Biocatalysis Regioselective nitrilase Regioselectivity Molecular modifications Industrial applications
- Significantly enhancing the stereoselectivity of a regioselective nitrilase for the production of (S)-3-cyano-5-methylhexanoic acid using an MM/PBSA method被引量：11收藏
- 作者：Chen, Zhi Wang, Hualei Yang, Lin Jiang, Shuiqing Wei, Dongzhi
- 机构：East China Univ Sci & Technol
- 来源：CHEMICAL COMMUNICATIONS 2021
- 关键词：Binding energy - Molecular dynamics - Free energy - Hydrogen bonds
- Rational engineering of Acinetobacter tandoii glutamate dehydrogenase for asymmetric synthesis of l-homoalanine through biocatalytic cascades被引量：11收藏
- 作者：Wang, Liuzhu Diao, Shiqing Sun, Yangyang Jiang, Shuiqin Liu, Yan Wang, Hualei Wei, Dongzhi
- 机构：East China Univ Sci & Technol
- 来源：CATALYSIS SCIENCE & TECHNOLOGY 2021
- 关键词：Amino acids - Substrates - Catalyst activity - Efficiency - Mass transfer - Hydrophobicity
- Energy and conformation determine the enantioselectivity of enzyme被引量：8收藏
- 作者：Gao, Bei Jiang, Shuiqin Wang, Liuzhu Zhang, Lujia Wei, Dongzhi
- 机构：East China Univ Sci & Technol;East China Normal Univ;NYU Shanghai
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2018
- 关键词：Chiral selectivity Free energy Structural conformation Rational design Lipase
- Switching the secondary and natural activity of Nitrilase from Acidovorax facilis 72 W for the efficient production of 2-picolinamide被引量：7收藏
- 作者：Wang, Liuzhu Jiang, Shuiqin Sun, Yangyang Yang, Zeyu Chen, Zhi Wang, Hualei Wei, Dongzhi
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2021
- 关键词：Biocatalyst Catalytic Promiscuity Nitrilase ProtEIn Engineering 2-Picolinamide
- Rational hinge engineering of carboxylic acid reductase from Mycobacterium smegmatis enhances its catalytic efficiency in biocatalysis被引量：6收藏
- 作者：Wang, Liuzhu Sun, Yangyang Diao, Shiqing Jiang, Shuiqin Wang, Hualei Wei, Dongzhi
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY JOURNAL 2022
- 关键词：carboxylic acid reductases hinge region protEIn engineering rational design virtual mutation
