文献类型：期刊文献

英文题名：A facile protocol for the synthesis of 4-aryl-1,4,7,8-tetrahydro-3,5- dimethyldipyrazolo[3,4-b:4′,3′-e]pyridine derivatives by a Hantzsch-type reaction

作者：Zhao, Kun[1]; Lei, Min[1]; Ma, Lei[2]; Hu, Lihong[1]

机构：[1] Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai 201203, China; [2] School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China

年份：2011

卷号：142

期号：11

起止页码：1169

外文期刊名：Monatshefte fur Chemie

收录：EI(收录号：20242616515713)

语种：英文

外文关键词：Catalysts - Condensation reactions - Environmental impact - Pyridine - Synthesis (chemical)

摘要：A facile and efficient protocol is described for the synthesis of 4-aryl-1,4,7,8-tetrahydro-3,5-dimethyldipyrazolo[3,4-b:4′,3′-e] pyridine derivatives in good yields by the condensation of 3-methyl-1H-pyrazol- 5(4H)-one, aromatic aldehydes, and ammonium acetate under catalyst-free conditions. The advantages of this protocol are operational simplicity, mild reaction conditions, high yields, and little environmental impact. Graphical abstract: [Figure not available: see fulltext.] ? 2011 Springer-Verlag.