文献类型：期刊文献

英文题名：Enantioselective Synthesis of Tetrahydropyrano[3,4-b]indoles Catalyzed by Chiral N-Triflyl Phosphoramide via Intramolecular Friedel-Crafts Alkylation Reaction

作者：Zhang, Jun-Wei[1,2];Cai, Quan[2];Shi, Xiao-Xin[1];Zhang, Wei[2];You, Shu-Li[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2011

期号：9

起止页码：1239

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000290856900005)，CCR-EXPANDED(收录号:WOS:000290856900005)】；

基金：We thank the NSFC (20732006, 21025209) and MOST (973 Program 2010CB833300) for financial support.

语种：英文

外文关键词：asymmetric catalysis; chiral Bronsted acids; N-triflyl phosphoramide; Friedel-Crafts; indoles

摘要：A highly efficient intramolecular enantioselective Friedel-Crafts alkylation reaction of indolyl enones utilizing chiral N-triflyl phosphoramide catalyst is described. Various tetrahydropyrano[3,4-b]indoles (THPI) have been afforded with excellent yields and up to 98% ee.