文献类型：期刊文献

英文题名：Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity

作者：Cao, H. L.[1,2,3];Dong, Y. X.[4];Aied, A.[4];Zhao, T. Y.[4];Chen, X.[1,2,3];Wang, W. X.[4];Pandit, A.[5]

机构：[1]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Biomed Nanotechnol Ctr, Shanghai 200237, Peoples R China;[4]Univ Coll Dublin, Charles Inst Dermatol, Dublin, Ireland;[5]Natl Univ Ireland, Network Excellence Funct Biomat, Galway, Ireland

年份：2014

卷号：50

期号：98

起止页码：15565

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000345207900019)】；

基金：We gratefully acknowledge the financial support from Shanghai Pujiang Program (13PJ1401700) and the European Commission under the DISC REGENERATION project (NMP3-LA-2008-213904).

语种：英文

摘要：An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. The degradation of the polymer was strongly pH-dependent. High nucleic acid transfection efficiency with low cytotoxicity was observed compared to its non-degradable copolymer counterpart.