文献类型：期刊文献

英文题名：A peptide probe for the detection of neurokinin-1 receptor by disaggregation enhanced fluorescence and magnetic resonance signals

作者：Wu, Jingxian[1,2];Zou, Rongfeng[1,2];Wang, Qi[3];Xue, Yajing[4];Wei, Ping[5];Yang, Shiping[6];Wu, Junchen[1,2];Tian, He[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem Inst, Shanghai 200237, Peoples R China;[3]Nantong Univ, Coll Publ Hlth, Nantong 226019, Jiangsu, Peoples R China;[4]Nantong Tumor Hosp, Clin Lab, Nantong 226006, Jiangsu, Peoples R China;[5]Fudan Univ, Shanghai Canc Ctr, Inst Canc, Shanghai 200032, Peoples R China;[6]Shanghai Normal Univ, Dept Chem, Shanghai 200234, Peoples R China

年份：2014

卷号：4

外文期刊名：SCIENTIFIC REPORTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000342906500001)】；

基金：We thank the National Basic Research 973 Program (2013CB733700), the Fundamental Research Funds for the Central Universities (WJ1213007), and the Innovation Program of Shanghai Municipal Education Commission (J100-2-13104) for financial support.

语种：英文

摘要：We report a novel peptide probe for the detection of neurokinin-1 receptor using disaggregation-caused signal enhancement. The probe was obtained via the aggregation of a modified substance P in a terpyridine-Fe (II) complex with Gd (III)-DOTA into well-defined nanostructures, which effectively weaken ligand fluorescence and slow the exchange rate of inner-sphere water molecules. This probe disaggregatesupon binding to the neurokinin-1 receptor and activates the contrast agents to generate a fluorescent signal that positively enhances magnetic resonance imaging contrast and allows for the detection of overexpressed receptors on tumor cells and the identification of lung cancer using serum samples.