文献类型：期刊文献

英文题名：Nanodrug Delivery Systems Modulate Tumor Vessels to Increase the Enhanced Permeability and Retention Effect

作者：Huang, Dong[1,2];Sun, Lingna[1,2];Huang, Leaf[3];Chen, Yanzuo[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ,Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[3]Univ North Carolina, Eshelman Sch Pharm, Div Pharmacoengn & Mol Pharmaceut, Chapel Hill, NC 27599 USA

年份：2021

卷号：11

期号：2

外文期刊名：JOURNAL OF PERSONALIZED MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000622756900001)】；

基金：This work of L.H. was funded by the Carolina Center for Cancer Nanotechnology Excellence, United States (NIH grant CA198999). Y.C. is supported by the Natural Science Foundation of Shanghai (19ZR1472500).

语种：英文

外文关键词：nanoparticles; tumor vascular regulation; EPR effect; angiogenesis; blood perfusion; vascular permeability

摘要：The use of nanomedicine for antitumor therapy has been extensively investigated for a long time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently regarded as an effective way to bring drugs to tumors, especially macromolecular drugs and drug-loaded pharmaceutical nanocarriers. However, a disordered vessel network, and occluded or embolized tumor blood vessels seriously limit the EPR effect. To augment the EPR effect and improve curative effects, in this review, we focused on the perspective of tumor blood vessels, and analyzed the relationship among abnormal angiogenesis, abnormal vascular structure, irregular blood flow, extensive permeability of tumor vessels, and the EPR effect. In this commentary, nanoparticles including liposomes, micelles, and polymers extravasate through the tumor vasculature, which are based on modulating tumor vessels, to increase the EPR effect, thereby increasing their therapeutic effect.