文献类型：期刊文献

英文题名：Fluid flow effects on the degradation kinetics of bioresorbable polymers

作者：Liu, Zhitao[1];Zhang, Hongbo[1];Lai, Huanxin[1]

机构：[1]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai, Peoples R China

年份：2021

卷号：24

期号：10

起止页码：1073

外文期刊名：COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

收录：;EI(收录号：20211210109111);WOS:【SCI-EXPANDED(收录号:WOS:000628706200001)】；

基金：The authors would like to acknowledge gratefully the financial support by the Shanghai Science and Technology Innovation Program (No. 19441909600) and the Opening project of Shanghai Key Laboratory of Orthopedic Implant (KFKT2019001).

语种：英文

外文关键词：Stent; biodegradable polymers; flow velocity; degradation

摘要：Implants, tissue engineering scaffolds made of biodegradable polymers are widely used in biomedical engineering. The degradation of polymers plays a critical role in the effectiveness of these applications. In this paper, the mechanism of the hydrolytic degradation affected by the flow medium is studied. The results indicate that both high porosity and dynamic conditions may significantly slow down degradation speed. A critical value of the Reynolds number is found to exist. When the Reynolds number is higher than the critical value, the autocatalysis was suppressed. The models reported in this article might serve as a guide to design 3D biodegradable implants.