文献类型：期刊文献

英文题名：Copper-catalyzed α-aminoxylation of 1,3-dicarbonyl compounds with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) via an aerobic oxidative sp3 C-H bond activation

作者：Luo, Xiaoyan[1,2];Wang, Zheng-Lin[1,2];Jin, Jing-Hai[1,2];An, Xing-Lan[1,2];Shen, Zhenlu[3];Deng, Wei-Ping[1,2,3]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

年份：2014

卷号：70

期号：44

起止页码：8226

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000343843900003)，CCR-EXPANDED(收录号:WOS:000343843900003)】；

基金：This work was financially supported by the Fundamental Research Funds for the Central Universities, the National Natural Science Foundation of China (21172068, 21376224) and Opening Foundation of Zhejiang Key Course of Chemical Engineering and Technology, Zhejiang University of Technology (20130211).

语种：英文

外文关键词：alpha-Aminoxylation; Copper; TEMPO; 1,3-Dicarbonyl compounds

摘要：A facile and direct synthetic method for the construction of alkoxyamine derivatives through copper-catalyzed aerobic oxidative activation of sp(3) C-H bond was developed in good to excellent yields (75 -95%), by treating the readily available 1,3-dicarbonyl compounds with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and its derivatives. This method was also successfully applied to the preparation of quaternary alpha-fluorinated alpha-hydroxyl acid derivatives. (C) 2014 Elsevier Ltd. All rights reserved.