文献类型：期刊文献

英文题名：Photothermal therapy enhance the anti-mitochondrial metabolism effect of lonidamine to renal cell carcinoma in homologous-targeted nanosystem

作者：Chen, Jiyuan[1];Ren, Fuzheng[2];Cao, Wenfeng[2];Wu, Zhengjie[3];Ju, Guanqun[3];Xiao, Chengwu[3];Wu, Weijia[1];Gao, Shen[3];Xu, Chuanliang[3];Gao, Yuan[1,3]

机构：[1]Fudan Univ, Sch Pharm, Dept Clin Pharm & Pharmaceut Management, Shanghai 201203, Peoples R China;[2]East China Univ Sci & Technol, Dept Pharm, Shanghai, Peoples R China;[3]Second Mil Med Univ, Changhai Hosp, Dept Urol, Shanghai, Peoples R China

年份：2021

卷号：34

外文期刊名：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE

收录：;EI(收录号：20211410166893);WOS:【SCI-EXPANDED(收录号:WOS:000661767200005)】；

基金：This work was supported by the National Natural Science Foundation of China [grant numbers 81972392, 81672545 and 81972391].

语种：英文

外文关键词：Renal cell carcinoma; Lonidamine; Polydopamine; Photothermal therapy; Mitochondrial metabolism

摘要：Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system with poor prognosis. Therapeutic drugs for RCC can easily develop resistance or have unignorable toxicity or limited efficiency. Here, the thermosensitive mitochondrial metabolism-interfering anticancer drug lonidamine (LND) was combined with the photothermal material polydopamine (PDA) to treat RCC. To delivery drugs accurately to RCC site, LND and PDA were loaded in stellate mesoporous silica nanoparticles (MSNs) with a large surface area and cloaked with RCC membranes (MLP@M). The results showed that MLP@M exhibited excellent tumor targeting ability. The synergistic effects of LND and PDA in MLP@M were greatly enhanced when triggered by an 808 nm laser. Moreover, the antiproliferative and tumor suppressing abilities were enhanced with good biocompatibility after MLP@M + laser treatment. Additionally, 80% of RCC tumor-bearing mice treated with MLP@M + laser did not relapse. Our study provides a potential therapeutic approach for RCC treatment. (c) 2021 Elsevier Inc. All rights reserved.