文献类型：期刊文献

英文题名：Discovery of a novel family of polycyclic aromatic molecules with unique reactivity and members valuable for fluorescent sensing and medicinal chemistry

作者：Xiao, Yi[1];Liu, Fengyu[1];Chen, Zhuo[2];Zhu, Weipin[2];Xu, Yufang[2];Qian, Xuhong[2]

机构：[1]Dalian Univ Technol, State Key Lab Fine Chem, Dalian, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2015

卷号：51

期号：30

起止页码：6480

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000352269000002)】；

基金：The authors are grateful for financial support from the National Natural Science Foundation of China (No. 21236002, 21421005, 21376038) and the National Basic Research Program of China (No. 2013CB733702).

语种：英文

摘要：A novel polycyclic aromatic molecule, i.e. 1-oxo-1H-phenalene-2,3-dicarbonitrile (compound 1, initially misidentified as 8-oxo-8H-acenaphtho[1,2-b]pyrrolecarbonitrile) was discovered by our group in 2005. This parent compound is highlighted for its unique oxidative SNArH (nucleophilic substitution of aromatic hydrogen) reactivity that provides easy approaches to diverse derivatives with different long-wavelength fluorescence and important biological activities. To date, a large number of derivatives have been synthesized and evaluated by several international research groups, indicating the formation of a new and valuable family of functional chemicals. Some members have been functionalized for molecular or nanoparticle-based probes applicable in chemical and environmental sensing, biomolecule imaging and tumor diagnosis. Others have qualified as high potency anticancer agents specifically targeting different functional proteins in tumor cells. With regard to the increasing attention paid to this new chemical family, it is a good time to review major achievements in order to promote further and deeper investigation.