文献类型：期刊文献

英文题名：Preparation of an Environmentally Friendly Formulation of the Insecticide Nicotine Hydrochloride through Encapsulation in Chitosan/Tripolyphosphate Nanoparticles

作者：Yang, Ying[1,2];Cheng, Jiagao[3];Garamus, Vasil M.[4];Li, Na[5];Zou, Aihua[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Appl Chem, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[4]Helmholtz Zentrum Geesthacht, Ctr Mat & Coastal Res, D-21502 Geesthacht, Germany;[5]Shanghai Inst Biochem & Cell Biol, Natl Ctr Prot Sci Shanghai, Shanghai 200237, Peoples R China

年份：2018

卷号：66

期号：5

起止页码：1067

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20180704807829);WOS:【SCI-EXPANDED(收录号:WOS:000424851900003)】；

基金：The present study was supported by grants from the National Key Research and Development Plan (2017YFD0200306), the National Natural Science Foundation of China (31200617), and the Knowledge Innovation Program of Chinese Academy of Sciences (CAS, Grant 2013KIP103).

语种：英文

外文关键词：nicotine; chitosan; tripolyphosphate; ionic gelification; monovalent salt effect; environmentally safe formulations

摘要：Insecticide nicotine hydrochloride (NCT) was formulated as nanoparticles composed of chitosan (CS) and sodium tripolyphosphate (TPP) to undermine its adverse impacts on human health and reinforce its physicochemical stability. The study investigated the preparation and characterization of chitosan/tripolyphosphate nanoparticles (CS/TPP NPs) with good encapsulation efficiency (55%), uniform morphology, and physicochemical stability (45 days) through dynamic light scattering (DLS), transmission electron microscopy (TEM), and small-angle X-ray scattering (SAXS) measurements. A bioassay against Musca domestica NCT CS/TPP NPs exhibited good bioactivity and thermal stability. The effect of the monovalent salt (NaCl) on manipulating the formation and size distribution of ionically cross-linked nanoparticles was demonstrated as well. The formulation of NCT CS/TPP NPs could be a utility candidate in public health and agriculture.