文献类型：期刊文献

英文题名：Lewis Acid-Catalyzed C(sp3)-C(sp3) Bond Forming Cyclization Reactions for the Synthesis of Tetrahydroprotoberberine Derivatives

作者：Li, Jianjun[1,2];Qin, Cong[1,2];Yu, Yang[1,2];Fan, Huaqiang[1,2];Fu, Yiwei[1,2];Li, Hao[1,2];Wang, Wei[1,2,3]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, State Key Lab Bioengn Reactor, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2017

卷号：359

期号：13

起止页码：2191

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000404514500004)，CCR-EXPANDED(收录号:WOS:000404514500004)】；

基金：Financial support of this research from the program for the National Science Foundation of China (21372073, 21572054 and 21572055), the Fundamental Research Funds for the Central Universities and East China University of Science and Technology, and the China 111 Project is gratefully acknowledged.

语种：英文

外文关键词：annulation; azaarene activation; C(sp(3))-C(sp(3)) bond formation; Lewis acid catalysis; tetrahydroprotoberberine derivatives

摘要：An efficient Lewis acid-catalyzed C(sp(3))-C(sp(3)) bond forming annulation reaction has been developed. This strategy serves as a new method for the facile synthesis of tetrahydro-5H-isoquinolino[2,1-g][1,6] naphthyridine derivatives. A wide range of 2-methylquinoline-3-carbaldehydes and 1,2,3,4-tetrahydroisoquinolines can be applied for this process to afford structurally diverse tetrahydroprotoberberine derivatives in excellent yields.