文献类型：期刊文献

英文题名：Diketopiperazine and Diphenylether Derivatives from Marine Algae-Derived Aspergillus versicolor OUCMDZ-2738 by Epigenetic Activation

作者：Liu, Wen[1,2];Wang, Liping[2];Wang, Bin[1];Xu, Yanchao[2];Zhu, Guoliang[3,4];Lan, Mengmeng[3];Zhu, Weiming[2,3,5];Sun, Kunlai[1]

机构：[1]Zhejiang Ocean Univ, Sch Marine Sci & Technol, Sch Food & Pharm, Zhejiang Prov Engn Technol Res Ctr Marine Biomed, Zhoushan 316022, Peoples R China;[2]Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China;[3]Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao 266003, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[5]Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, Qingdao 266237, Peoples R China

年份：2019

卷号：17

期号：1

外文期刊名：MARINE DRUGS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000458053200006)】；

基金：This research was financially supported by the NSFC (Nos. 81803423 & 41376148), Natural Science Foundation of Zhejiang (No. LQ18D060005), the 100 Leading Talents of Guizhou Province (fund for W.Z.), the science and technology project of Guizhou (No. QKHT Z-2014-4007) and the academician workstation of Guizhou (No. QKH YSZ-2015-4009).

语种：英文

外文关键词：chemical-epigenetic method; endophytic fungus; Aspergillus versicolor; enantiomer; antimicrobial activity

摘要：A chemical-epigenetic method was used to enhance the chemodiversity of a marine algicolous fungus. Apart from thirteen known compounds, (+)-brevianamide R ((+)-3), ()-brevianamide R (()-3), (+)-brevianamide Q ((+)-4), ()-brevianamide Q (()-4), brevianamide V ((+)-5), brevianamide W (()-5), brevianamide K (6), diorcinol B (7), diorcinol C (8), diorcinol E (9), diorcinol J (10), diorcinol (11), 4-methoxycarbonyldiorcinol (12), two new compounds, (+)- and ()-brevianamide X ((+)- and ()- 2)), as well as a new naturally occurring one, 3-[6-(2-methylpropyl)-2-oxo-1H-pyrazin-3-yl]propanamide (1), were isolated from chemical-epigenetic cultures of Aspergillus versicolor OUCMDZ-2738 with 10 mu M vorinostat (SAHA). Compared to cultures in the same medium without SAHA, compounds 1-4, 8, 9, 11, and 12 were solely observed under SAHA condition. The structures of these compounds were elucidated based on spectroscopic analysis, specific rotation analysis, ECD, and X-ray crystallographic analysis. (+/-)-3, (+/-)-4, and (+/-)-5 were further resolved into the corresponding optically pure enantiomers and their absolute configurations were determined for the first time. Compounds 11 and 12 showed selective antibacterial against Pseudomonas aeruginosa with a minimum inhibitory concentration (MIC) of 17.4 and 13.9 M, respectively. Compound 10 exhibited better -glucosidase inhibitory activity than the assay control acarbose with IC50 values of 117.3 and 255.3 M, respectively.