文献类型：期刊文献

英文题名：Developmental and cardiovascular toxicities of acetochlor and its chiral isomers in zebrafish embryos through oxidative stress

作者：Wang, Xin[1];Chen, Fan[1];Lu, Jian[1];Wu, Mengqi[1];Cheng, Jiagao[1];Xu, Wenping[1];Li, Zhong[1];Zhang, Yang[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2023

卷号：896

外文期刊名：SCIENCE OF THE TOTAL ENVIRONMENT

收录：;EI(收录号：20232814379797);WOS:【SCI-EXPANDED(收录号:WOS:001039482700001)】；

基金：This work was fi nancially Sponsored by the National Key Research and Development Plan (2022YFD1700502) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Acetochlor; Zebrafish; Chiral isomers; Developmental toxicity; Cardiovascular toxicity

摘要：Acetochlor (ACT) is a widely used pesticide, yet the environmental and health safety of its chiral isomers remains inadequately evaluated. In this study, we evaluated the toxicity of ACT and its chiral isomers in a zebrafish model. Our findings demonstrate that ACT and its chiral isomers disrupt early zebrafish embryo development, inducing oxidative stress, abnormal lipid metabolism, and apoptosis. Additionally, ACT and its chiral isomers lead to cardiovascular damage, including reduced heart rate, decreased red blood cell (RBC) flow rate, and vascular damage. We further observed that (+)-S-ACT has a significant impact on the transcription of genes involved in cardiac and vascular development, including tbx5, hand2, nkx2.5, gata4, vegfa, dll4, cdh5, and vegfc. Our study highlights the potential risk posed by different conformations of chiral isomeric pesticides and raises concerns regarding their impact on human health. Overall, our results suggest that the chiral isomers of ACT induce developmental defects and cardiovascular toxicity in zebrafish, with (+)-S-ACT being considerably more toxic to zebrafish than (-)-R-ACT.