文献类型：期刊文献

英文题名：The effect of polymeric chain-like structure on the degradation and cellular biocompatibility of calcium polyphosphate

作者：Wang, Kai[1,2];Chen, Fangping[1,2];Liu, Changsheng[1,2];Ruessel, Christian[3]

机构：[1]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[3]Univ Jena, Otto Schott Inst, D-07743 Jena, Germany

年份：2008

卷号：28

期号：8

起止页码：1572

外文期刊名：MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS

收录：;EI(收录号：20084711731972);WOS:【SCI-EXPANDED(收录号:WOS:000261848600056)】；

基金：The authors are grateful to the National Science Fund for Distinguished Young Scholars (No. 204256), National Natural Science Foundation of China (Nos. 50732002, 20425621, 30670568), Outstanding academic leaders of Shanghai (No. 07XD14008) and Nano special program of Science and Technology Development of Shanghai (No. 0652nm021) for the financial support.

语种：英文

外文关键词：Calcium polyphosphate; Polymeric structure; Controllable degradation; Cytotoxicity

摘要：Three-dimensional porous calcium polyphosphate (CPP) scaffolds were fabricated in the present work. We investigated the degradation mechanism of CPP from the viewpoint of polymeric structure and the effects of different polymeric structure on cell viability. By controlling the sintering temperature and altering the proportion of hydrolytic groups (Q(1) groups) in polyphosphate chain. CPP can be obtained respectively with different degradation rate. The results suggested that with increasing sintering temperature, the proportion of Q(1) groups in polyphosphate chain decreased. CPP sintered at 550 degrees C had 15.1% Q(1) groups in polyphosphate chain, while CPP sintered at 650 degrees C and 750 degrees C exhibited 10.5 and 8.3%, respectively. During immersion in simulated body fluid (SBF) for 30 days, the weight loss of CPP sintered at 550 degrees C was about 80%, while CPP sintered at 650 degrees C and 750 degrees C degraded by only 8% and 5%. Cell viability test results showed that the porous CPP did not exert cytotoxicity effect on the cells after being cultured 6 days. Due to the lower degradation rate, CPP sintered at 750 degrees C showed better cell attachment and proliferation as well as higher cell density. These findings may provide an approach to study and achieve controllable degradation of CPP, and explore more biomedical applications. (C) 2008 Elsevier B.V. All rights reserved.