文献类型：期刊文献

中文题名：金属-聚多巴胺基复合材料设计及其生物医学应用

英文题名：Fabrication of Metal-Polydopamine Based Composites and Their Biomedical Applications

作者：魏肖轶[1];曹渊渊[1];李永生[1]

机构：[1]华东理工大学材料科学与工程学院,上海200237

年份：2026

卷号：57

期号：2

起止页码：365

中文期刊名：高分子学报

外文期刊名：Acta Polymerica Sinica

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001716330200003)】；北大核心:【北大核心2023】；

基金：国家重点研发项目(项目号2022YFC2403200);国家自然科学基金(基金号22472058)。

语种：中文

中文关键词：聚多巴胺;金属-聚多巴胺复合材料;生物医用材料;材料生物学效应;多酚化学

外文关键词：Polydopamine;Metal-polydopamine composites;Biomedical materials;Materiobiological effects;Polyphenol chemistry

摘要：聚多巴胺是一种典型的黑色素衍生人工分子,其具有高黏附、生物相容性好、易修饰、光热活性高等诸多优良性质,在能源催化、表面化学以及生物医药领域具有广泛的应用.金属-聚多巴胺复合纳米材料源于聚多巴胺对多种金属离子的强亲和力,其充分利用聚多巴胺的优良生物学效应,得益于不同金属独特的理化特征,具有抗肿瘤、抗菌消炎、抗氧化、免疫激活及促细胞再生等多种生物学功能,在肿瘤诊疗一体化、伤口愈疗、组织修复再生等领域展现出良好的应用前景.本文聚焦5大类型金属-聚多巴胺复合材料,基于不同金属独到的生物学优势,综述了金属-聚多巴胺复合材料的设计合成、理化性质及其近年来在生物医学领域的典型应用,并展望了该类材料在未来临床转化及工业化生产方面面临的挑战和机遇.通过本文详细的总结,有望启发设计更多新型金属-聚多巴胺类复合材料,挖掘更多聚多巴胺基新型生物医用材料的应用潜力,促进多酚化学与生物医学的进一步融合.
Polydopamine is a typical melanin-derived artificial molecule.It has numerous excellent properties such as high adhesion,good biocompatibility,easy modification,and high photothermal activity,and thus has wide applications in the fields of energy catalysis,surface chemistry,and biomedicine.Metal-polydopamine composite nanomaterials are fabricated based on the strong binding affinity of polydopamine for various metal ions.They make full use of the excellent biological effects of polydopamine,benefiting from the unique physical and chemical characteristics of different metals,possess multiple biological functions including anti-tumor,antibacterial,anti-inflammatory,antioxidant,immune activation,and cell regeneration promotion.These materials show promising application prospects in areas such as integrated tumor diagnosis and treatment,wound healing,and tissue repair and regeneration.This review focuses on five major types of metal-polydopamine composites,which contain unique biological advantages originated from different metals.This paper also reviews the design and synthesis,physical and chemical properties of metal-polydopamine composites,as well as their typical applications in the biomedical field in recent years.It also summarized the challenges and opportunities that these materials face in future clinical translation and industrial production.Through the detailed summary in this review,it is expected to inspire the design of more novel metal-polydopamine composites,promote the explore of the application potential of novel polydopamine based biomedical materials,and promote the further integration of polyphenol chemistry and biomedicine.