文献类型：期刊文献

英文题名：Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from Streptomyces sp. MS751

作者：Yu, Jiaming[1];Guo, Hui[2];Zhang, Jing[3,4];Hu, Jiansen[2,5];He, Hongtao[2];Chen, Caixia[6,7];Yang, Na[2];Yang, Fan[3,4];Lin, Zexu[1];Dai, Huanqin[2];Ouyang, Liming[1];Liu, Cuihua[2];Lei, Xiaoguang[3,4];Zhang, Lixin[1,2];Zhu, Guoliang[1];Song, Fuhang[2,8]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China;[3]Peking Univ, Coll Chem & Mol Engn, Dept Chem Biol, Beijing Natl Lab Mol Sci,Key Lab Bioorgan Chem Mol, Beijing 100871, Peoples R China;[4]Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China;[5]Univ Chinese Acad Sci, Beijing 100049, Peoples R China;[6]Chinese Acad Sci, Inst Microbiol, Technol Transfer Ctr, Beijing 100101, Peoples R China;[7]Univ Pittsburgh, Sch Med, Pittsburgh, PA 15213 USA;[8]Beijing Technol & Business Univ, Sch Light Ind, Key Lab Geriatr Nutr & Hlth, Minist Educ China, Beijing, Peoples R China

年份：2024

卷号：22

期号：6

外文期刊名：MARINE DRUGS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001257095200001)】；

基金：This research was funded by The National Key Research and Development Program of China, 2022YFC2105400 and 2017YFD0201203; the National Natural Science Foundation of China,3143002, 31320103911, 31600017, 31500690, 31600136; and 21625201, 21561142002, 21472010; and Ministry of Science and Technology of China, 2015CB856200.

语种：英文

外文关键词：tuberculosis; Streptomyces; antibiotics; chrysomycin; biomimetic synthesis

摘要：A new dimeric C-glycoside polyketide chrysomycin F (1), along with four new monomeric compounds, chrysomycins G (2), H (3), I (4), J (5), as well as three known analogues, chrysomycins A (6), B (7), and C (8), were isolated and characterised from a strain of Streptomyces sp. obtained from a sediment sample collected from the South China Sea. Their structures were determined by detailed spectroscopic analysis. Chrysomycin F contains two diastereomers, whose structures were further elucidated by a biomimetic [2 + 2] photodimerisation of chrysomycin A. Chrysomycins B and C showed potent anti-tuberculosis activity against both wild-type Mycobacterium tuberculosis and a number of clinically isolated MDR M. tuberculosis strains.