文献类型：期刊文献

英文题名：Intelligent Molybdenum Disulfide Complexes as a Platform for Cooperative Imaging-Guided Tri-Mode Chemo-Photothermo-Immunotherapy

作者：Hu, Wei[1,2];Xiao, Tingting[1];Li, Du[1];Fan, Yu[1];Xing, Lingxi[2];Wang, Xipeng[2];Li, Yulin[3];Shi, Xiangyang[1,4];Shen, Mingwu[1]

机构：[1]Donghua Univ, Coll Chem Chem Engn & Biotechnol, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China;[2]Shanghai Jiao Tong Univ, XinHua Hosp, Sch Med, Dept Gynecol & Obstet, Shanghai 200092, Peoples R China;[3]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ,State Key Lab B, Shanghai 200237, Peoples R China;[4]Univ Madeira, CQM Ctr Quim Madeira, P-9020105 Funchal, Portugal

年份：2021

卷号：8

期号：14

外文期刊名：ADVANCED SCIENCE

收录：;EI(收录号：20212510526658);WOS:【SCI-EXPANDED(收录号:WOS:000662853000001)】；

基金：This research has been financially supported by the National Key R&D Program (No. 2017YFE0196200), the National Natural Science Foundation of China (Nos. 81761148028, 81801704 and 21773026), the Science and Technology Commission of Shanghai Municipality (Nos. 18YF1415300, 19410740200, 20520710300, and 19XD1400100), and the Fundamental Research Funds for the Central Universities (T. Xiao).

语种：英文

外文关键词：immunogenic cell death; molybdenum disulfide; multimode imaging; polydopamine; tri-mode chemophotothermo-immunotherapy of tumors

摘要：Design of new nanoplatforms that integrates multiple imaging and therapeutic components for precision cancer nanomedicine remains to be challenging. Here, a facile strategy is reported to prepare polydopamine (PDA)-coated molybdenum disulfide (MoS2) nanoflakes as a nanocarrier to load dual drug cisplatin (Pt) and 1-methyl-tryptophan (1-MT) for precision tumor theranostics. Preformed MoS2 nanoflakes are coated with PDA, modified with methoxy-polyethylene glycol (PEG)-amine, and loaded with 1-MT and Pt. The formed functional 1-MT-Pt-PPDA@MoS2 (the second P stands for PEG) complexes exhibit good colloidal stability and photothermal conversion efficiency (47.9%), dual pH-, and photothermal-sensitive drug release profile, and multimodal thermal, computed tomography and photoacoustic imaging capability. Due to the respective components of Pt, MoS2, and 1-MT that can block the immune checkpoint associated to tumoral indoleamine 2,3-dioxygenase-induced tryptophan metabolism, tri-mode chemo-photothermo-immunotherapy of tumors can be realized. In particular, under the near infrared laser irradiation, fast release of both drugs can be facilitated to achieve cooperative tumor therapy effect, and the combined immunogenic cell death induced by the dual-mode chemo-photothermo treatment and the 1-MT-induced immune checkpoint blockade can boost enhanced antitumor immune response to generate significant cytotoxic T cells for tumor killing. The developed 1-MT-Pt-PPDA@MoS2 complexes may be used as an intelligent nanoplatform for cooperative precision imaging-guided combinational tumor therapy.