文献类型：期刊文献

英文题名：Visible-light induced cross-electrophile coupling of imines and anhydrides to synthesize α-amino ketones

作者：Cao, Renxu[1,2];Liu, Yu[1,2];Shi, Xiaoxin[1,2];Zheng, Jun[1,2]

机构：[1]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2023

卷号：59

期号：71

起止页码：10668

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20233614674278);WOS:【SCI-EXPANDED(收录号:WOS:001047920100001)，CCR-EXPANDED(收录号:WOS:001047920100001)】；

基金：23ZR141740023ZR1417400 The authors are grateful for the financial support received from the Shanghai Scientific and Technological Innovation Projects (Grant No. 23ZR1417400), the East China University of Science and Technology for startup funding, and the Program of Introducing Talents of Discipline to Universities (Grant No. YC0142206 and YC0142208). The authors wish to thank the staff of the Research Center of Analysis and Testing of East China University of Science and Technology for their help with the NMR analysis.

语种：英文

摘要：alpha-Amino ketones are important motifs in synthetic and medicinal chemistry. Efficient methods to directly access these motifs from feasible precursors are, however, limited. Herein, a visible-light mediated reductive cross-electrophile coupling of readily available imines and anhydrides was developed. Under mild reaction conditions, the umpolung reactivity of diverse imines engaged with anhydrides gives a variety of alpha-amino ketones with good yields and a broad functional group compatibility. Primary mechanistic studies revealed that this transformation might proceed through a radical-radical cross coupling pathway dominantly.