文献类型：期刊文献

英文题名：A crosslinked colloidal network of peptide/nucleic base amphiphiles for targeted cancer cell encapsulation

作者：Zhou, Yanzi[1,2];Qiu, Peng[1,2];Yao, Defan[3];Song, Yanyan[1,2];Zhu, Yuedong[1,2];Pan, Haiting[1,2];Wu, Junchen[1,2];Zhang, Junji[1,2]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Radiol, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China

年份：2021

卷号：12

期号：29

起止页码：10063

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20213110708806);WOS:【SCI-EXPANDED(收录号:WOS:000669081400001)】；

基金：The authors acknowledge financial support from the NSFC (21878086, 21788102) and the Shanghai Rising-Star Program (19QA1402500 to JZ). The project was supported by the Shanghai Municipal Science and Technology Major Project (Grant No. 2018SHZDZX03), the International Cooperation Program of Shanghai Science and Technology Committee (17520750100), and the Fundamental Research Funds for the Central Universities (222201717003).

语种：英文

外文关键词：Biocompatibility - Cells - Diseases - Cytology - Amphiphiles - Peptides

摘要：The use of peptide amphiphiles (PAs) is becoming increasingly popular, not only because of their unique self-assembly properties but also due to the versatility of designs, allowing biological responsiveness, biocompatibility, and easy synthesis, which could potentially contribute to new drug design and disease treatment concepts. Oligonucleotides, another major functional bio-macromolecule class, have been introduced recently as new functional building blocks into PAs, further enriching the tools available for the fabrication of bio-functional PAs. Taking advantage of this, in the present work, two nucleic base-linked (adenine, A and thymine, T) RGD-rich peptide amphiphiles (NPAs) containing the fluorophores naphthalimide and rhodamine (Nph-A and Rh-T) were designed and synthesized. The two NPAs exhibit distinctive assembly behaviours with spherical (Rh-T) and fibrous (Nph-A) morphologies, and mixing Nph-A with Rh-T leads to a densely crosslinked colloidal network (Nph-A/Rh-T) via mutually promoted supramolecular polymerization via nucleation-growth assembly. Because of the RGD-rich sequences in the crosslinked network, further research on in situ targeted cancer cell (MDA-MB-231) encapsulation via RGD-integrin recognition was performed, and the modulation of cell behaviours (e.g., cell viability and migration) was demonstrated using both confocal laser scanning microscopy (CLSM) imaging and a scratch wound healing assay.