文献类型：期刊文献

中文题名：从肌苷简便合成腺苷

英文题名：Simple Synthesis of Adenosine from Inosine

作者：冀亚飞[1];许煦[2]

机构：[1]华东理工大学药学院,上海200237;[2]华东理工大学化工学院,上海200237

年份：2007

卷号：24

期号：8

起止页码：971

中文期刊名：应用化学

外文期刊名：Chinese Journal of Applied Chemistry

收录：CSTPCD;;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

基金：华东理工大学科研基金资助项目

语种：中文

中文关键词：腺苷;肌苷;核苷;合成

外文关键词：adenosine,inosine,nucleoside,synthesis

摘要：在不改变骨架的前提下提出一种从肌苷通过官能团转换制备腺苷的工艺方法,总收率可达62%。肌苷在醋酸钠存在下与醋酸酐发生酯化反应以92%的收率得到2′,3′,5′-三乙酰肌苷,其化合物经吡啶和三氯氧磷处理形成吡啶盐溶液,未分离直接在40℃、0.25～0.30MPa压力下进行氨解反应以67%产率制得腺苷。腺苷结构经1HNMR、MS测试技术确证。这种简便的腺苷合成方法可适合于工业化生产。
A synthetic process of adenosine was performed from inosine by a conversion of functional groups with an overall yield of 62%. With sodium acetate as catalyst, inosine was esterified with acetic anhydride in the yield of 92% to give 2＇ ,3＇ ,5＇-triacetyl inosine, which was treated with pyridine and phosphorus oxychlo- ride to form a pyridinium solution, followed by performing an amination at 40 ℃ and 0. 25 - 0. 30 MPa to achieve adenosine in the yield of 67%. The structure of adenosine was confirmed by means of ^1H NMR, MS. This simple synthesis of adenosine is accessible to an industrial scale.