文献类型：期刊文献

英文题名：Highly Efficient Synthesis of (R)-3-Quinuclidinol in a Space-Time Yield of 916 g L-1 d-1 Using a New Bacterial Reductase ArQR

作者：Zhang, Wen-Xia[1];Xu, Guo-Chao[1];Huang, Lei[1];Pan, Jiang[1];Yu, Hui-Lei[1];Xu, Jian-He[1]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Lab Biocatalysis & Synthet Biotechnol, Shanghai 200237, Peoples R China

年份：2013

卷号：15

期号：19

起止页码：4917

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000326320200001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No 21276082), Ministry of Science and Technology, P. R. China (Nos. 2011CB710800 and 2011AA02A210), Shanghai Commission of Science and Technology (No. 11431921600), and Huo Yingdong Education Foundation.

语种：英文

摘要：A new keto reductase (ArQR), identified from Agrobacterium radiobacter ECU2556, can efficiently reduce 3-quinuclidinone in excellent enantioselectivity and high space-time yield for the synthesis of (R)-3-quinuclidinol, a chiral building block of many antimuscarinic agents. This is the first time that a high yield of (R)-3-quinuclidinol up to 916 g L-1 d(-1) using a bioreduction approach is reported.