文献类型：期刊文献

中文题名：器官芯片及其应用

英文题名：Organs-on-chips and Its Applications

作者：孙威[1];陈雨晴[1];罗国安[2,3];张敏[3];章弘扬[1];王月荣[1];胡坪[1]

机构：[1]上海市功能性材料化学重点实验室,华东理工大学化学与分子工程学院,上海200237;[2]清华大学化学系,北京100084;[3]华东理工大学药学院上海市新药设计重点实验室,上海200237

年份：2016

卷号：44

期号：4

起止页码：533

中文期刊名：分析化学

外文期刊名：Chinese Journal of Analytical Chemistry

收录：CSTPCD;;EI(收录号：20181304950309);Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000375130600003)】；北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：This work was supported by the National Science and Technology Major Project for Significant New Drugs Development of China (No. 2013ZX09507005).

语种：中文

中文关键词：微流控芯片;器官芯片;细胞;人体器官;综述

外文关键词：Microfluidic chip; Organs-on-chips; Cell; Human organ; Review

摘要：微流控芯片是细胞体外培养的重要平台,基于该平台所发展的器官芯片技术更因其能够模拟人体器官的复杂结构及功能而受到重视。本文从不同器官的角度介绍了近年来器官芯片技术在构建人体生理学模型、药物研发及毒理学研究中的应用,并对器官芯片技术的发展前景进行了展望。
Microfluidic chips are significant platforms of cell culture in vitro. Microfluidic chip-based organson-chips technology has received attention because it can mimic the complex structures and functions of human organs. In this review,the recent advances of organs-on-chips technology in different organs are reported including the build of human physiological models, drug discovery and toxicology research. And the development of this technology is proposed.