文献类型：期刊文献

英文题名：A Fluorogenic ONOO--Triggered Carbon Monoxide Donor for Mitigating Brain Ischemic Damage

作者：Xing, Linfeng[1];Wang, Bin[2,3];Li, Jin[1];Guo, Xinjian[2];Lu, Xicun[1];Chen, Xiaohua[1];Sun, Haitao[4];Sun, Zhenrong[4];Luo, Xiao[5];Qi, Suhua[2,3];Qian, Xuhong[1,5];Yang, Youjun[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Xuzhou Med Univ, Sch Med Technol, Xuzhou Key Lab Lab Diagnost, Xuzhou 221004, Jiangsu, Peoples R China;[3]Xuzhou Med Univ, Dept Lab Med, Affiliated Hosp, Xuzhou 221004, Jiangsu, Peoples R China;[4]East China Normal Univ, Sch Phys & Elect Sci, State Key Lab Precis Spect, Shanghai 200241, Peoples R China;[5]East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China

年份：2022

卷号：144

期号：5

起止页码：2114

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20220611602970);WOS:【SCI-EXPANDED(收录号:WOS:000766221400014)】；

基金：This work was supported by the National Natural Science Foundation of China (21822805, 21908065, 12034008, 81671164, and 22078098), the Natural Science Foundation of Jiangsu Province (BK20211348), the China Postdoctoral Science Foundation (2019M651427 and 2020T130197), the Research Funds of Happiness Flower ECNU (2020JK2103), and the Shanghai Rising-Star Program (21QA1402600).

语种：英文

外文关键词：Cell death

摘要：Ischemia-reperfusion (I/R) injuries are from the secondary radicals of ONOO-. Direct radical scavenging is difficult because of their high reactivity. ONOO- is longer-lived than the radicals in the biological milieu. Scavenging ONOO- suppresses radical generation preventively. CO is neuroprotective during ischemia. With the scaffold of carbon-caged xanthene, we designed an OONO--triggered CO donor (PCOD585). Notably, PCOD585 exhibited a concomitant fluorescence turn-on upon ONOO- detection, facilitating microscopic monitoring. PCOD585 was cytoprotective in oxygen-glucose deprivation (OGD)-insulted PC-12 cells. It was permeable to the blood-brain barrier and further exhibited neuroprotective effects to MCAO rats by reducing infarction volume, cell apoptosis, and brain edema.