文献类型：期刊文献

英文题名：One-Pot Three-Component Access to Furan and Thiophene Derivatives

作者：Bao, Ruipeng[1,2];Wang, Yao[1,2];Lin, Xinbo[1,2];Tan, Jinglin[1,2];Chen, Zhihua[3];Wang, Teng[4];Yu, Xinhong[1,2]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Shanghai Key Lab New Drug Design, Sch Pharm,Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioengn Reactors, Shanghai 200237, Peoples R China;[3]Shanghai Aoqi Pharmaceut Co, Shanghai, Peoples R China;[4]Beijing Inst Petrochem Technol, Coll Chem Engn, Beijing 102617, Peoples R China

年份：2025

卷号：36

期号：07

起止页码：841

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001363421400001)，CCR-EXPANDED(收录号:WOS:001363421400001)】；

基金：We gratefully acknowledge financial support from the National Natural Science Foundation of China (No. 21476078, X.-H.Y.) and the Science and Technology Commission of Shanghai Municipality (No.12431900902, X.-H.Y.).

语种：英文

外文关键词：one-pot reaction; multicomponent reaction; furans; thiophenes; cascade reaction

摘要：The furan and thiophene skeleton structures are widely present in natural products and synthetic drugs, and display multiple bioactivities. An effective one-pot three-component reaction to access furan and thiophene derivatives from 2-bromo-5-(dichloromethyl)furan or-thiophene; cyanoacetate esters, cyanoacetamides, or malononitrile; and aliphatic secondary amines has been developed. The multicomponent reaction for the construction of new C-N and C-C bonds in one pot is simple, mild, and efficient, and the yield of the target product is as high as 96%.