文献类型：期刊文献

中文题名：氧化硅基杂化胶束负载Flav7光热剂的合成与性能研究

英文题名：Flav7-loaded Silica-based Hybrid Micelles: Synthesis and Photothermal Performance

作者：池哲人[1];张辽[2];郭志前[2];李永生[1,3];牛德超[1]

机构：[1]华东理工大学材料科学与工程学院,上海200237;[2]华东理工大学化学与分子工程学院,上海200237;[3]石河子大学化学化工学院,石河子832003

年份：2022

卷号：37

期号：11

起止页码：1236

中文期刊名：无机材料学报

外文期刊名：Journal of Inorganic Materials

收录：CSTPCD;;EI(收录号：20230513465360);Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000886593900009)】；北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：National Natural Science Foundation of China (52072124); Natural Science Foundation of Shanghai (20ZR1414900)

语种：中文

中文关键词：Flav7;氧化硅基材料;胶束;光热性能

外文关键词：Flav7;silica-based material;micelle;photothermal property

摘要：近年来,由于具有较好的近红外区吸收、结构可调等特点,有机小分子光热剂在生物医药领域展示出广阔的应用前景。然而,大部分有机小分子光热剂仍面临水溶性较差、生物稳定性不佳、光热转换效率较低等挑战。本研究发展了一种简便的合成方法,制备了负载Flav7的氧化硅基杂化胶束(FPOMs)用于高效的光热治疗。首先利用嵌段共聚物PS_(132)-b-PAA_(16)自组装行为负载疏水近红外有机小分子Flav7得到胶束体系,进一步引入3-巯基丙基三甲氧基硅烷(MPTMS)和聚乙二醇(PEG)对上述胶束体系进行结构固定和表面改性得到FPOMs。研究表明,在808 nm波长激光的激发下, FPOMs展现出优异的光热稳定性和较高的光热转换效率(46.7%)。细胞实验证实FPOMs具有良好的生物相容性和光热毒性,有望作为一类新型的纳米光热剂用于肿瘤高效安全光热治疗。
Recently, organic small molecule photothermal agents have great application potentials in the field of biomedicine due to their high extinction coefficient in the near-infrared region and good structural tunability. Unfortunately, most current organic small molecular photothermal agents prove to be still poor water solubility, unsatisfactory biological stability, and low photothermal conversion efficiency. To address these, a simple method was developed to prepare Flav7-loaded silica-based hybrid micelles(FPOMs) for efficient photothermal therapy. Firstly, the Flav7-loaded micelles were prepared by self-assembly of block copolymer PS_(132)-b-PAA_(16). Then, 3-mercaptopropyl trimethoxysilane(MPTMS) and polyethylene glycol(PEG) were introduced to fix the structure and endowed the surface modification of the system, respectively, resulting in the final formation of FPOMs. Results show that FPOMs exhibit excellent photothermal stability and high photothermal conversion efficiency(46.7%) under the excitation of 808 nm laser. Cell experiments indicate that FPOMs have good biocompatibility and photothermal toxicity. It is highly expected to be used as a new type of nano-photothermal agent for efficient and safe photothermal therapy.