文献类型：期刊文献

英文题名：Multiple Myeloma Tumor Cells are Selectively Killed by Pharmacologically-dosed Ascorbic Acid

作者：Xia, Jiliang[1,2];Xu, Hongwei[1];Zhang, Xiaoyan[1,3];Allamargot, Chantal[4];Coleman, Kristen L.[1];Nessler, Randy[4];Frech, Ivana[1];Tricot, Guido[1];Zhan, Fenghuang[1]

机构：[1]Univ Iowa, Holden Comprehens Canc Ctr, Dept Med, Div Hematol Oncol & Blood & Marrow Transplantat, Iowa City, IA 52242 USA;[2]Southern Med Univ, Inst Canc Res, Sch Basic Med Sci, Guangzhou, Guangdong, Peoples R China;[3]East China Univ Sci & Technol, Shanghai, Peoples R China;[4]Univ Iowa, Cent Microscopy Res Facil, Iowa City, IA USA

年份：2017

卷号：18

起止页码：41

外文期刊名：EBIOMEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000402105100014)】；

基金：The data presented in this article were obtained at the Central Microscopy Research Facility, which is a Carver College of Medicine/Holden Comprehensive Cancer Center core research facility at the University of Iowa. The Facility is funded through user fees and the generous financial support of the Carver College of Medicine, Holden Comprehensive Cancer Center grant P30CA086862 and NIH grant 1S10RR018998-01. This work was also supported by NIH grants R01CA152105 (F.Z.), the Multiple Myeloma Research Foundation (F.Z.), the International Myeloma Foundation (F.Z.), the American Society of Hematology (ASH) Bridge (F.Z.), the UIHC-CCOM Research Investment Pilot Grants (F.Z.) and institutional start-up funds from the Department of Internal Medicine, Carver College of Medicine, University of Iowa (F.Z. and G.T.).

语种：英文

外文关键词：Multiple myeloma; Pharmacologically-dosed ascorbic acid; Apoptosis-inducing factor 1

摘要：High-dose chemotherapies to treat multiple myeloma (MM) can be life-threatening due to toxicities to normal cells and there is a need to target only tumor cells and/or lower standard drug dosage without losing efficacy. We show that pharmacologically-dosed ascorbic acid (PAA), in the presence of iron, leads to the formation of highly reactive oxygen species (ROS) resulting in cell death. PAA selectively kills CD138(+) MM tumor cells derived from MM and smoldering MM (SMM) but not from monoclonal gammopathy undetermined significance (MGUS) patients. PAA alone or in combination with melphalan inhibits tumor formation in MM xenograft mice. This study shows PAA efficacy on primary cancer cells and cell lines in vitro and in vivo. (C) 2017 The Authors. Published by Elsevier B.V.