文献类型：期刊文献

中文题名：有机酸杂质对乳酸锌初次成核速率的影响

英文题名：Effect of impurity on primary nucleation kinetics of zinc lactate

作者：张相洋[1];周兴贵[1];钱刚[1];袁渭康[1]

机构：[1]华东理工大学化学工程联合国家重点实验室,上海200237

年份：2011

卷号：62

期号：5

起止页码：1302

中文期刊名：化工学报

外文期刊名：CIESC Journal

收录：CSTPCD;;EI(收录号：20112714112399);Scopus;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：上海市科委国际科技合作项目(06SR07108);化学工程联合国家重点实验室开放课题(Skloche-08C08);国家自然科学基金项目(20476026)~~

语种：中文

中文关键词：成核;乳酸锌;杂质;初次成核动力学

外文关键词：nucleation; zinc lactate; impurity; primary nucleation kinetics

摘要：引言溶液结晶作为一种高效、低能耗、少污染的分离和提纯技术,在医药、食品、生物等工业生产中的应用非常广泛。特别在医药行业,溶液结晶是主要的单元操作,85%以上的医药产品的生产过程中含有结晶单元。
An approach was proposed to determine the solubility of pure zinc lactate at a high heating rate（20 K·h-1）,which significantly improves the efficiency of solubility measurement.The results showed a good agreement with the solubility data obtained through isothermal processes.This approach was extended to measure the solubility of zinc lactate in the presence of small amount of impurity.The influences of impurities,including malic acid,succinic acid and sodium oxalate,on the primary nucleation kinetics of zinc lactate in cooling crystallization were investigated,and a method was presented to estimate the primary nucleation kinetics based on Nvlt theory by measuring the metastable zone width of zinc lactate at specific cooling rate in the solution.The results showed that the rate of primary nucleation of zinc lactate decreased in the presence of malic acid or succinic acid.However,when sodium oxalate was introduced in the solution,the nucleation of zinc lactate was accelerated at low supersaturation but suppressed at high supersaturation.