文献类型：期刊文献

英文题名：A general approach to the design of high-performance near-infrared (NIR) D-π-A type fluorescent dyes

作者：Luo, Xiao[1];Li, Jin[2];Zhao, Jie[2];Gu, Luyan[2];Qian, Xuhong[1,2];Yang, Youjun[2]

机构：[1]East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：30

期号：4

起止页码：839

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000468254500003)】；

基金：The work is supported by the National Natural Science Foundation of China (Nos. 21574039 and 21822805) and Shanghai Municipal Science and Technology Commission (No. 18DZ1112703).

语种：英文

外文关键词：Near infrared; Polymethine cyanine; Fluorescence; Steric protection; Rigidity

摘要：Near infrared (NIR) absorbing and emitting dyes are sought after for their potentials in bioimaging and theranostic applications. They are typically not as stable as dyes absorbing and emitting in the visible spectral range, as the result of a reduced HOMO-LUMO band-gap. Also, they are not as efficient fluorescence emitters due to accelerated internal conversion kinetics. In addition, their large conjugative backbone render them high tendency to form aggregate and low aqueous solubility. In this tutorial, we have described a four-step approach for rational design of organic dyes with an overall high-performance to meet the rigorous requirements of biological applications. Also, some background regarding "NIR" is provided along with some recent breakthroughs of the field. (C) 2019 Chinese Chemical Society and Institute of Materia Medics, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.