文献类型：期刊文献

英文题名：Highly efficient synthesis of aryl ketones by PEPPSI-palladium catalyzed acylative Suzuki coupling of amides with diarylborinic acids

作者：Wang, Chen[1];Huang, Lingyun[1];Wang, Fengze[1];Zou, Gang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai, Peoples R China

年份：2018

卷号：59

期号：23

起止页码：2299

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000446641000021)，CCR-EXPANDED(收录号:WOS:000446641000021)】；

基金：This work was financially supported by the National Natural Science Foundation of China (21472041).

语种：英文

外文关键词：Acylative Suzuki coupling; N-heterocyclic carbene; Aryl ketones; Amides; Diarylborinic acid

摘要：An improved acylative cross-coupling of various N-methyl-N-tosyl amides with diarylborinic acids for synthesis of aryl ketones is developed. In most cases, aryl ketones could be obtained in excellent yields by using 1 mol% 2,6-diisopropylphenylimidazolylidene and 3-chloropyridine co-supported palladium chloride as catalyst in the presence of 3 equiv. K2CO3 as base in refluxing THF. The readily prepared and cost-effective substrates, N-methyl-N-tosylamides and diarylborinic acids, and the commercially available catalyst system promise a practical and efficient access to aryl ketones. (C) 2018 Elsevier Ltd. All rights reserved.