文献类型：期刊文献

英文题名：Recent progress on molecularly near-infrared fluorescent probes for chemotherapy and phototherapy

作者：Yan, Chenxu[1];Zhang, Yutao[1];Guo, Zhiqian[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem,Inst Fine Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：427

外文期刊名：COORDINATION CHEMISTRY REVIEWS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000588407500038)】；

基金：This work was supported by the NSFC/China (21788102, 21878087 and 21908060), the Innovation Program of Shanghai Municipal Education Commission (2019-01-07-00-02-E00060), the Shuguang Program (18SG27), and the China Postdoctoral Science Foundation (2019M651417), and Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Near-infrared; Fluorescent probe; Prodrug; Photodynamic therapy; Photothermal therapy

摘要：Recently, molecularly fluorophores for nanotheranostics, bridging in vivo imaging and therapeutic capability within unimolecular system, has attracted increasing attention. Compared with the visible fluorescence imaging, near-infrared (NIR) fluorescence imaging possesses unique advantages including low background, deep penetration, and minimal damage to biological tissues. Based on the typical high-performance fluorophores, we highlight the recent progress on molecularly NIR fluorescent probes for in vivo chemotherapy and phototherapy with a particular focus on their design strategy and functionalization. Current challenges and future perspectives of molecularly NIR fluorescent theranostics in bringing forth clinical applications for personalized treatment are also discussed. (C) 2020 Elsevier B.V. All rights reserved.