文献类型：期刊文献

英文题名：Highly Regioselective Synthesis of N-β-trifluoromethyl 2-pyridones via anti-Markovnikov Hydroamination of α-(trifluoromethyl)styrenes with 2-pyridones

作者：Zhang, Yi[1];Sun, Zhudi[1];He, Jingjing[1];Deng, Yupian[1];Liu, Ying[1];Zheng, Pai[1];Cao, Song[1,2]

机构：[1]East China Univ Sci & Technol ECUST, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

年份：2023

卷号：18

期号：10

外文期刊名：CHEMISTRY-AN ASIAN JOURNAL

收录：;EI(收录号：20231713949521);WOS:【SCI-EXPANDED(收录号:WOS:000976298400001)】；

语种：英文

外文关键词：alpha-(trifluoromethyl)styrenes; hydroamination; N-beta-trifluoromethyl 2-pyridones; regioselectivity; 2-pyridones

摘要：A novel and facile method for the synthesis of N-beta-CF3-substituted 2-pyridones via hydroamination of alpha-(trifluoromethyl)styrenes with 2-pyridones was described. The reaction proceeded smoothly at room temperature, affording a variety of N-(beta-trifluoromethyl-beta-arylethyl)pyridin-2(1H)-ones in moderate to good yields with excellent N-regioselectivity.