文献类型：期刊文献

英文题名：Structurally Rigid 9-Amino-benzo[c]cinnoliniums Make Up a Class of Compact and Large Stokes-Shift Fluorescent Dyes for Cell-Based Imaging Applications

作者：Shen, Yanming[2];Shang, Zhihao[2];Yang, Yanhong[3];Zhu, Shaojia[1];Qian, Xuhong[1,2];Shi, Ping[1];Zheng, Jing[3];Yang, Youjun[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2015

卷号：80

期号：11

起止页码：5906

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20152400930110);WOS:【SCI-EXPANDED(收录号:WOS:000355962300057)】；

基金：We thank Dr. Yongli Zheng of Shanghai Jiaotong University for the fluorescence lifetime studies. The work is supported by the Shanghai Rising-Star Program (13QA1401200), the Doctoral Fund of the Ministry of Education of China (20110074120008), and the National Natural Science Foundation of China (21106043 and 21372080).

语种：英文

外文关键词：C (programming language)

摘要：Classic fluorescent dyes, such as coumarin, naphthalimide, fluorescein, BODIPY, rhodamine, and cyanines, are cornerstones of various spectroscopic and microscopic methods, which hold a prominent position in biological studies. We recently found that 9-amino-benzo[c]cinnoliniums make up a novel group of fluorophores that can be used in biological studies. They are featured with a succinct conjugative push-pull backbone, a broad absorption band, and a large Stokes shift. They are potentially useful as a small-molecule alternative to R-phycoerythrin to pair with fluorescein in multiplexing applications.