文献类型：期刊文献

英文题名：Micellar carrier based on methoxy poly(ethylene glycol)-block-poly(ε-caprolactone) block copolymers bearing ketone groups on the polyester block for doxorubicin delivery

作者：He Yueying[1];Zhang Yan[1];Gu Chunhua[1];Dai Weifeng[1];Lang Meidong[1,2]

机构：[1]E China Univ Chem Technol, Sch Mat Sci & Engn, Minist Educ, Shanghai Key Lab Adv Polymer Mat,Key Lab Ultrafin, Shanghai 200237, Peoples R China;[2]Fudan Univ, Minist Educ, Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China

年份：2010

卷号：21

期号：2

起止页码：567

外文期刊名：JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

收录：;EI(收录号：20101712885636);WOS:【SCI-EXPANDED(收录号:WOS:000274436300022)】；

基金：This research was supported by the National Natural Science Foundation of China (20674019 and 20804015), "Shu Guang'' Project of Shanghai Municipal Education Commission, Specialized Research Fund for the Doctoral Program of Higher Education (20060251015, 200802511021), the Natural Science Foundation of Shanghai, (08ZR1406000), Shanghai Key Laboratory Project (08DZ2230500) and Shanghai Leading Academic Discipline Project (B502).

语种：英文

外文关键词：Targeted drug delivery - Micelles - Motion Picture Experts Group standards - Nuclear magnetic resonance spectroscopy - Polyols - Controlled drug delivery - Hydrophobicity - Dialysis membranes - Ethylene glycol - Ketones - Polyethylene glycols

摘要：Block copolymers of Methoxy poly(ethylene glycol)-block-poly(epsilon-caprolactone) bearing ketone groups (MPEG-b-P(CL-co-OPD)) are synthesized and evaluated for its potential to form micelles containing doxorubicin (DOX), a representative anticancer drug, by using an in vitro method based on membrane dialysis to emulate drug release in vivo. The H-1 NMR spectra of the prepared block copolymers in D2O solution exhibit peaks due to the P(OPD-co-CL) in decreased intensity, indicates that the polymers form micelle particles containing the hydrophilic segments in their external parts. The CMC of the copolymer decrease with an increase in the content of ketone groups in the hydrophobic chain. Drug-free and drug-loaded solutions of structurally related copolymers indicate the polymeric aggregation into micellar-type constructs. The size of the drug-loaded micelles is found to be larger than corresponding drug-free micelles. The release rate of MPEG-b-PCL micelles is faster than MPEG-b-P(OPD-co-CL) micelles in pH 7.4 buffered solution and they have a similar release rate in pH 5.0 buffered solution. This study, therefore, confirms the potential of a novel functional block copolymers, Methoxy poly(ethylene glycol)-block-poly(epsilon-caprolactone) bearing ketone Groups, for the formation of polymeric micelles for drug delivery.