文献类型：期刊文献

中文题名：Functionalization of small black phosphorus nanoparticles for targeted imaging and photothermal therapy of cancer

英文题名：Functionalization of small black phosphorus nanoparticles for targeted imaging and photothermal therapy of cancer

作者：Lijuan Deng[1,2];Yifan Xu[1,2];Caixia Sun[2];Baofeng Yun[3];Qiao Sun[2];Chongjun Zhao[1];Zhen Li[2]

机构：[1]Key Laboratory for Ultrafine Materials of Ministry of Education. Shanghai Key Laboratory of Advanced Polymeric Materials, School of Material Science and Engineering, East China University of Science and Technology, Shanghai 200237, China;[2]Center for Molecular imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (PAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China;[3]College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China

年份：2018

卷号：63

期号：14

起止页码：917

中文期刊名：Science Bulletin

外文期刊名：科学通报（英文版）

收录：Scopus;CSCD:【CSCD2017_2018】；

基金：support from the National Natural Science Foundation of China(81471657,81527901);the 1000 Plan for Young Talents,Jiangsu Specially Appointed Professorship;Jiangsu Provincial Program for Innovative and Entrepreneurial Talents;support from the Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection;the Priority Academic Development Program of Jiangsu Higher Education Institutions(PAPD)

语种：英文

中文关键词：Black phosphorus;Functionalization;Targeted imaging;Photothermal therapy

外文关键词：荧光成像;癌症;治疗;指向;磷;近红外线;poly;变换效率

摘要：Black phosphorus(BP) nanomaterials have attracted extensive attention due to their unique physical,chemical, and biological properties. In this study, small BP nanoparticles were synthesized and modified with dextran and poly(ethyleneimine) for functionalization with folic acid and cyanine 7. The functionalized BP nanoparticles exhibit excellent biocompatibility, stability, and near infrared optical properties for targeted imaging of tumors through photoacoustic imaging and near-infrared fluorescence imaging.They also display high photothermal conversion efficiency for photothermal therapy of cancer. This work demonstrates the potential of functionalized small BP nanoparticles as an emerging nanotheranostic agent for the diagnosis and treatment of cancer.
Black phosphorus （BP） nanomaterials have attracted extensive attention due to their unique physical, chemical, and biological properties. In this study, small BP nanoparticles were synthesized and modified with dextran and poly（ethyleneimine） for functionalization with folic acid and cyanine 7. The function- alized BP nanoparticles exhibit excellent biocompatibility, stability, and near infrared optical properties for targeted imaging of tumors through photoacoustic imaging and near-infrared fluorescence imaging. They also display high photothermal conversion efficiency for photothermal therapy of cancer. This work demonstrates the potential of functionalized small BP nanoparticles as an emerging nanotheranostic agent for the diagnosis and treatment of cancer.