文献类型：期刊文献

中文题名：肾小球滤过率活体实时监测荧光示踪剂的研究进展

英文题名：Recent Advances on Fluorescent Tracers for in vivo Real-time Monitoring Glomerular Filtration Rate

作者：丁奕如[1];张超颖[1];谢贺新[1]

机构：[1]华东理工大学药学院,上海市新药设计重点实验室,上海200237

年份：2022

卷号：43

期号：12

起止页码：339

中文期刊名：高等学校化学学报

外文期刊名：Chemical Journal of Chinese Universities

收录：CSTPCD;;EI(收录号：20230113339858);Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000905161200001)】；北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：Supported by the National Natural Science Foundation of China(Nos.22077031, 22277027)and the Fundamental Research Funds for the Central Universities, China.

语种：中文

中文关键词：肾小球滤过率;荧光示踪剂;实时监测;急性肾损伤

外文关键词：Glomerular filtration rate(GFR);Fluorescent tracer;Real-time monitoring;Acute kidney injury

摘要：急性肾损伤是一种临床常见的急性疾病.通过外源性的荧光示踪剂对肾小球滤过率进行非侵入性的实时监测,对于及时了解易患病人的肾脏功能具有重要的临床价值和应用前景.本文综合评述了用于活体检测肾小球滤过率的外源性荧光示踪剂的近期研究进展,重点介绍了荧光示踪剂的设计策略及其活体成像应用效果,并对相应检测装置的发展进行了阐述,同时对该领域的挑战与发展前景进行了展望.
Acute kidney injury(AKI)is a commonly encountered clinical acute disease.Monitoring glomerular filtra?tion rate(GFR)with exogenous fluorescent tracers in a non-invasive and real-time manner is of high importance in clinical practice for timely understanding of renal function in susceptible patients.This paper gives a comprehensive review of recent advances on exogenous fluorescent tracers for in vivo monitoring of glomerular filtration rate,with particular focus on the design strategy of fluorescent tracers and their application on in vivo imaging,as well as the development of corresponding detection devices.In the last part,we discuss the challenges and the development prospect in this field.