文献类型：期刊文献

英文题名：Host Defense Peptide-Mimicking Poly(2-oxazoline)s Displaying Potent Activities toward Phytopathogens to Alleviate Antimicrobial Resistance in Agriculture

作者：Chen, Sheng[1];Zhou, Min[1];Xiao, Ximian[1];Xie, Jiayang[1];Liu, Longqiang[1];Cong, Zihao[1];Zhao, Xuebin[1];Hu, Weilong[1];Wang, Jie[2,3];Song, Gonghua[4];Liu, Runhui[1,5,6]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[2]China Railway Acad Grp Co Ltd, Chengdu 610032, Sichuan, Peoples R China;[3]China Railway Cultural Heritage Rehabil Technol In, Chengdu 610032, Sichuan, Peoples R China;[4]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai, Peoples R China;[5]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomed Mat, Engn Res Ctr Biomed Mat,Minist Educ,Sch Mat Sci &, Shanghai 200237, Peoples R China;[6]Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Suzhou 215163, Peoples R China

年份：2025

卷号：73

期号：14

起止页码：8191

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20251318146413);WOS:【SCI-EXPANDED(收录号:WOS:001455566900001)】；

基金：This research was supported by the National Natural Science Foundation of China (No. T2325010, 22305082), Science and Technology Research and Development Plan of China Railway Co., Ltd. (2023-Major Project-02). We thank the staff members of the Integrated Laser Microscopy System at the National Facility for Protein Science in Shanghai (NFPS), Shanghai Advanced Research Institute, Chinese Academy of Sciences, China for sample preparation, data collection and analysis. Thanks for the support of the Analysis and Testing Center of School of Chemical Engineering, East China University of Science and Technology.

语种：英文

外文关键词：host defense peptides; poly(2-oxazoline)s; phytopathogens; antimicrobial resistance

摘要：Given the limited types of agricultural bactericides and the rapid emergence of antimicrobial resistance, bacterial plant diseases pose a serious threat to agricultural production, which calls for effective antimicrobial agents with a low propensity for resistance. Host defense peptides (HDPs) have drawn significant attention for their broad-spectrum antimicrobial activity. In this study, we found that HPD-mimicking poly(2-oxazoline) Gly-POX20 exhibits potent activity against bacterial phytopathogens, with superior antibacterial selectivity and proteolytic stability compared to the natural HDP melittin. Compared to commonly used agricultural bactericides, Gly-POX20 displays more efficient antibiofilm activity and a lower propensity for resistance than does the antibiotic streptomycin, likely due to its antibacterial mechanism, which involves DNA interaction and generating lethal doses of ROS. In vivo studies reveal that Gly-POX20 is effective in preventing and treating phytopathogens without observable damage to plant tissues, suggesting that poly(2-oxazoline) could be a promising bactericide for agricultural applications.