文献类型：期刊文献

英文题名：An aptameric graphene nanosensor for analyte detection in serum

作者：Wang, Xuejun[1,2]; Zhu, Yibo[1]; Olsen, Timothy R.[1]; Sun, Na[3]; Zhang, Wenjun[2,4]; Pei, Renjun[3]; Lin, Qiao[1]

机构：[1] Columbia University, New York, NY, United States; [2] East China University of Science and Technology, Shanghai, China; [3] Suzhou Institute of Nano-Tech and Nano-Bionics, Suzhou, Jiangsu, China; [4] University of Saskatchewan, Saskatoon, SK, Canada

年份：2016

卷号：2016-February

起止页码：286

外文期刊名：Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

收录：EI(收录号：20162202452083)

语种：英文

外文关键词：MEMS - Carrier concentration - Nanosensors - Field effect transistors - Body fluids - Graphene transistors

摘要：We present an aptameric graphene field-effect transistor (GFET) nanosensor for sensitive and label-free detection of biomarkers in serum. The graphene nanosensor is serially functionalized with a polyethylene glycol (PEG) nanolayer and an aptamer for specific detection of a target analyte and effective rejection of background molecules in human serum. The analyte binds to the surface-immobilized aptamer, changing the carrier concentration in the graphene. The resulting changes in the conductance of the graphene is measured to determine the analyte concentration. Experimental results show that the device is capable of detecting immunoglobulin E (IgE) in serum in a clinically relevant range of 50 pM to 35 nM. ? 2016 IEEE.