文献类型：期刊文献

中文题名：Asymmetric synthesis of pyrrolo[1,2-a]indoles via organocatalytic[3+2]annulation of substituted 2-vinylindoles with azlactones

作者：Wulin Yang[1];Hao Wang[2];Zirong Pan[2];Zhong Li[1,3];Weiping Deng[2]

机构：[1]Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;[2]Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;[3]Shanghai Collaborative Innovation Center for Biomanufacturing Technology,Shanghai 200237,China

年份：2020

卷号：31

期号：3

起止页码：721

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；PubMed;

基金：supported by the Fundamental Research Funds for the Central Universities;the China Postdoctoral Science Foundation(Nos.2018M632037,2019T120310);Shanghai Sailing Program(No.18YF140560)。

语种：英文

中文关键词：[3+2]Annulation;Azlactones;2-Vinylindoles;Asymmetric;organocatalysis;Pyrrolo[1,2-a]indoles;Chiral;phosphoric;acid

摘要：The chiral phosphoric acid catalyzed asymmetric[3+2]annulation of substituted 2-vinylindoles with azlactones has been established.This reaction represented a practical approach for the synthesis of structurally diverse pyrrolo[1,2-a]indoles with two vicinal stereocenters including one tetrasubstituted stereocenter in good yields and good stereoselectivities under mild conditions.