文献类型：期刊文献

英文题名：A H2S-Generated Supramolecular Photosensitizer for Enhanced Photodynamic Antibacterial Infection and Relieving Inflammation

作者：Tian, Jia[1];Huang, Baoxuan[1];Xia, Lei[1];Zhu, Yucheng[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2024

卷号：11

期号：9

外文期刊名：ADVANCED SCIENCE

收录：;EI(收录号：20235115234499);WOS:【SCI-EXPANDED(收录号:WOS:001123904900001)】；

基金：J.T. and B.H. contributed equally to this work. The authors acknowledge the financial support from the National Natural Science Foundation of China (52333014, 22075079, 52203009), and the Science and Technology Commission of Shanghai Municipality (21ZR1417800, 21520713400 and 22142201100). The authors acknowledge the help of Prof. Gerald Guerin (East China University of Science and Technology, China) on the language polish and scientific discussion. All animal experiments in this study were performed in accordance with institutional guidelines and approved by the Laboratory Animal Centre of East China University of Science and Technology (ECUST-2022-010).

语种：英文

外文关键词：anti-inflammatory; hydrogen sulfide; photodynamic antibacterial; porphyrin; supramolecular photosensitizer

摘要：Photodynamic therapy (PDT) is a promising treatment against bacteria-caused infections. By producing large amounts of reactive oxygen species (ROS), PDT can effectively eliminate pathogenic bacteria, without causing drug resistance. However, excessive ROS may also impose an oxidative stress on surrounding tissues, resulting in local inflammation. To avoid this major drawback and limit pro-inflammation during PDT, this work prepared a supramolecular photosensitizer (TPP-CN/CP5) based on host-guest interactions between a cysteine-responsive cyano-tetraphenylporphyrin (TPP-CN) and a water-soluble carboxylatopillar[5]arene (CP5). TPP-CN/CP5 not only possesses excellent photodynamic antibacterial properties, but also shows good anti-inflammatory and cell protection capabilities. Under 660 nm light irradiation, TPP-CN/CP5 could rapidly produce abundant ROS for sterilization. After the PDT process, the addition of cysteine (Cys) triggers the release of H2S from TPP-CN. H2S then stops the induced inflammation by inhibiting the production of related inflammatory factors. Both in vitro and in vivo experiments show the excellent antibacterial effects and anti-inflammatory abilities of TPP-CN/CP5. These results will certainly promote the clinical application of PDT in the treatment of bacterial infectious diseases.