文献类型：期刊文献

英文题名：Iridium-Catalyzed Asymmetric Hydrogenation of Simple Ketones with Tridentate PNN Ligands Bearing Unsymmetrical Vicinal Diamines

作者：Zhang, Lei[2];Liu, Chengyu[2];Sun, Maolin[1];Liang, Chaoming[1];Cao, Liming[2];Yao, Xiantong[1];Ma, Yueyue[1];Cheng, Ruihua[1];Ye, Jinxing[1,2]

机构：[1]Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Shanghai Key Lab New Drug Design,Minist Educ, Shanghai 200237, Peoples R China

年份：2023

卷号：88

期号：5

起止页码：2942

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20230813625387);WOS:【SCI-EXPANDED(收录号:WOS:000935735400001)】；

基金：? ACKNOWLEDGMENTS This work was supported by the National Natural Science Foundation of China (no. 22071056,22278087) .

语种：英文

外文关键词：Amines - Chelation - Enantioselectivity - Hydrogenation - Iridium - Iron compounds - Ketones - Organometallics - Phosphorus compounds - Scaffolds

摘要：An iridium catalytic system with a ferrocene-based phosphine ligand bearing a modular and tunable unsymmetrical vicinal diamine scaffold was developed for the asymmetric hydrogenation of aryl ketones. This approach provided a powerful tool for the enantioselective synthesis of diverse chiral alcohols with excellent reactivity and enantioselectivity (up to 99% yield, up to 99% ee, and up to 50,000 turnover number). The substituents and chirality of unsymmetrical diamines in ligands played an important role in the satisfactory results.