文献类型：期刊文献

英文题名：Water dispersive upconversion nanoparticles for intelligent drug delivery system

作者：Li, Xiangye;Liu, Danyang;Wang, Yizhou;Xu, Shouhong[1];Liu, Honglai

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：555

起止页码：55

外文期刊名：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

收录：;EI(收录号：20182605384661);WOS:【SCI-EXPANDED(收录号:WOS:000443153100007)】；

基金：Financial support for this work was provided by the National Natural Science Foundation of China (No. 21776071) and the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002).

语种：英文

外文关键词：Upconversion nanoparticles; Azobenzene; NIR light; Drug release

摘要：A novel near-infrared (NIR)-induced drug release system has been designed in this paper, based on upconversion nanoparticles and photosensitive amphiphilic polymers. Y-type photosensitive amphiphilic molecule, which had an azobenzene moiety in both hydrophobic chains, was synthesized. The resultant product, azobenzene-polyethylene glycol (AZO-PEG), was quite sensitive to ultraviolet (UV) and visible light. The prepared upconversion nanoparticles of NaYF4:Tm,Yb@NaYF4:Er,Yb (UCNP) were turned out that they could transfer NIR light into UV and blue light simultaneously. AZO-PEG and UCNP were mixed and self-assembled to an UCNP@AZO-PEG coreshell assembly. It was found that the assembly, UCNP@AZO-PEG, underwent isomerization upon irradiation with UV/visible light alternately as well as upconversion upon NIR light irradiation. As a model drug, doxorubicin (DOX) could be loaded into the assembly and released triggered by NIR light and different pH values, and the possible mechanism involved was discussed. The cell transfection results indicated that UCNP@AZO-PEG had good biocompatibility. Besides, DOX loaded in UCNP@AZO-PEG showed higher cell toxicity against HeLa cells.