文献类型：期刊文献

英文题名：Coupling PEG-LZM polymer networks with polyphenols yields suturable biohydrogels for tissue patching

作者：Tan, Haoqi[1];Sun, Junjie[1];Jin, Dawei[2];Song, Jialin[1];Lei, Miao[1];Antoshin, Artem[3];Chen, Xin[1];Yin, Meng[2];Qu, Xue[1];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Sch Med, Dept Cardiothorac Surg, 1678 Dong Fang Rd, Shanghai 200127, Peoples R China;[3]Sechenov Univ, Inst Regenerat Med, 8-2 Trubetskayast, Moscow 119991, Russia

年份：2020

卷号：8

期号：12

起止页码：3334

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20203809212113);WOS:【SCI-EXPANDED(收录号:WOS:000542957800006)】；

基金：This work was supported by National Natural Science Foundation of China (grant number: 51621002, 31922041, 51573047, and 21875066).

语种：英文

外文关键词：Hydrophobicity - Hydrogen bonds

摘要：Poor mechanical performances severely limit the application of hydrogelsin vivo; for example, it is difficult to perform a very common suturing operation on hydrogels during surgery. There is a growing demand to improve the mechanical properties of hydrogels for broadening their clinical applications. Natural polyphenols can match the potential toughening sites in our previously reported PEG-lysozyme (LZM) hydrogel because polyphenols have unique structural units including a hydroxyl group and an aromatic ring that can interact with PEGviahydrogen bonding and form hydrophobic interactions with LZM. By utilizing polyphenols as noncovalent crosslinkers, the resultant PEG-LZM-polyphenol hydrogel presents super toughness and high elasticity in comparison to pristine PEG-LZM with no obvious changes in the initial shape, and it can even withstand the high pressure from sutures. At the same time, the mechanical properties could be widely adjusted by varying the polyphenol concentration. Interestingly, the PEG-LZM-polyphenol hydrogel has a higher water content than other polyphenol-toughened hydrogels, which may better meet the clinical needs for hydrogel materials. Besides, the introduction of polyphenols endows the hydrogel with improved antibacterial and anti-inflammatory abilities. Finally, the PEG-LZM-polyphenol (tannic acid) hydrogel was demonstrated to successfully patch a rabbit myocardial defect by suturing for 4 weeks and improve the wound healing and heart function recovery compared to autologous muscle patches.