文献类型：期刊文献

英文题名：ZBTB34, a novel human BTB/POZ zinc finger protein, is a potential transcriptional repressor

作者：Qi, Jia; Zhang, Xin; Zhang, Hai-Kuo; Yang, Hong-Meng; Zhou, Yu-Bo; Han, Ze-Guang

机构：[1]Chinese Natl Human Genome Ctr, Shanghai 201203, Peoples R China;[2]E China Univ Sci & Technol, Sch Bioengn, Inst Biochem & Mol Biol, Shanghai 200237, Peoples R China

年份：2006

卷号：290

期号：1-2

起止页码：159

外文期刊名：MOLECULAR AND CELLULAR BIOCHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000240802100020)】；

语种：英文

外文关键词：BTB/POZ domain; nuclear protein; transcriptional repressor; ZBTB34

摘要：BTB/POZ protein family plays a key role in many biological processes both in Drosophila and vertebrates through regulating the transcriptional activities of some downstream genes. Here, we obtained a novel member of human BTB/POZ protein family, named as ZBTB34 (Zinc finger and BTB domain containing 34), which encodes 504 amino acid residues with a BTB/POZ domain at its N-terminus that is similar to the same domain of other known transcription regulators. RT-PCR analysis indicated that ZBTB34 was expressed ubiquitously in most adult human tissues, and whilst immunofluorescence assays showed that ZBTB34 was mainly localized to nucleus. Interestingly, the reporter assay in mammalian cells suggested that ZBTB34 might function as a transcriptional repressor. This present work as the first report about the functional exploration of the novel ZBTB34 gene would be contributed to profound understanding of the transcriptional regulation via BTB/POZ protein family.