文献类型：期刊文献

英文题名：Stimulation of cell responses and bone ingrowth into macro-microporous implants of nano-bioglass/polyetheretherketone composite and enhanced antibacterial activity by release of hinokitiol

作者：Zhang, Jue[1];Wei, Wu[2];Yang, Lili[3];Pan, Yongkang[1];Wang, Xuehong[1];Wang, Tinglan[1];Tang, Songchao[1];Yao, Yuan[1];Hong, Hua[1];Wei, Jie[1]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Nanjing Tech Univ, Coll Mat Sci & Engn, Nanjing 210009, Jiangsu, Peoples R China;[3]Second Mil Med Univ, Changzheng Hosp, Dept Orthopaed Surg, Shanghai 200003, Peoples R China

年份：2018

卷号：164

起止页码：347

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20180604767703);WOS:【SCI-EXPANDED(收录号:WOS:000429762100041)】；

基金：The grants were from the National key research and development program (2016YFC1102100), the National Natural Science Foundation of China (81771990, 81572194 and 51502340), and the Opening Project of Shanghai Key Laboratory of Orthopaedic Implants.

语种：英文

外文关键词：Nano bioactive glasses; Polyetheretherketone composite; Macro-microporous implant; Osteogenesis; Antibacterial activity

摘要：Poor osteogenesis and bacterial infection lead to the failure of implants, thus enhancements of osteogenic activity and antibacterial activity of the implants have significances in orthopedic applications. In this study, macro-microporous bone implants of nano-bioglass (nBG) and polyetheretherketone (PK) composite (mBPC) were fabricated. The results indicated that the mBPC with the porosity of around 70% exhibited interconnected macropores (sizes of about 400 mu m) and micropores (sizes of about 10 mu m). The apatite mineralization ability of mBPC in simulated body fluid (SBF) was significantly improved compared with macroporous nBG/PK composite (BPC) without micropores and macroporous PK (mPK). Drug of hinokitiol (HK) was loaded into mBPC (dmBPC), which displayed excellent in vitro antibacterial activity against Staphylococcus aureus. The MC3T3-E1 cells proliferation and ALP activity were significantly promoted by mBPC and dmBPC as compared with BPC and mPK. The micro-CT and histological evaluation showed that both mBPC and dmBPC containing nBG and micropores induced higher new bone formation into porous implants than mPK and BPC. The immunohistochemistry analysis indicated that the expression of BMP-2 in mBPC and dmBPC exhibited obviously higher level than mPK and BPC. The results suggested that the incorporation of nBG and micropores in mBPC obviously improved the osteogenic activity, and mBPC load with HK also promoted osteogenesis, indicating good biocompatibility. The dmBPC with HK significantly enhanced osteogenesis and antibacterial activity, which had great potential as bone implant for hard tissue repair. (C) 2018 Published by Elsevier B.V.