文献类型：期刊文献

中文题名：可注射PPF骨水泥的制备与固化性能

英文题名：Preparation and Curing Properties of Injectable PPF Bone Cement

作者：杨峰[1];马春蒙[1];王靖[1];刘昌胜[1]

机构：[1]华东理工大学教育部医用生物材料工程研究中心,上海200237

年份：2018

卷号：31

期号：1

起止页码：51

中文期刊名：功能高分子学报

外文期刊名：Journal of Functional Polymers

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD2017_2018】；

基金：国家科技支撑计划(2012BAl17B00)

语种：中文

中文关键词：固化性能;骨水泥;聚富马酸丙二醇酯

外文关键词：curing property;bone cement;poly(propylene fumarate)

摘要：首先以富马酸二乙酯、1,2-丙二醇为原料,通过两步法制备了聚富马酸丙二醇酯(PPF)树脂,然后加入引发剂、交联剂、促进剂制备了PPF骨水泥。采用温度测试、示差扫描量热法(DSC)以及力学测试考察了PPF骨水泥的交联固化时间、交联放热温度以及压缩强度等性能。探讨了PPF的分子量、交联剂N-乙烯基吡咯烷酮(NVP)、引发剂过氧化苯甲酰(BPO)及促进剂N,N-二甲基对苯二胺(DMT)的用量对骨水泥固化性能的影响。结果表明:1g PPF树脂中加入0.25mL NVP、5mg BPO、20μL DMT制备的骨水泥具有较优的固化性能。与商品化聚甲基丙烯酸甲酯(PMMA)骨水泥相比,PPF骨水泥具有更好的力学性能和生物相容性,固化过程中放热温度较低。
Poly(propylene fumarate)(PPF)resin was synthesized by two-step method using diethyl fumarate and 1,2-propylene glycol as reactants.PPF bone cement was prepared by adding initiator,crosslinking agent and accelerator.A series of properties of PPF bone cement including crosslinking curing time,crosslinking exothermic temperature and compressive strength were inspected by temperature measurement,Differential Scanning Calorimetry(DSC)and mechanical strength test.The curing performance of bone cement was investigated using different molecular weights of PPF and different doses of additives,such as crosslinking agent(N-vinylpyrrolidone(NVP)),initiator(benzoyl peroxide(BPO))and accelerator(N,N-dimethyl p-toluidine(DMT)).Results show that PPF bone cement prepared by adding 0.25 mL NVP,5 mg BPO,20μL DMT to 1 g PPF resin has the best curing property.Compared with commercial poly(methyl methacrylate)(PMMA)cement,PPF bone cement has better mechanical properties and biocompatibility.Moreover,the reaction exothermic during the curing process is relatively low.