文献类型：期刊文献

英文题名：Reversible Redox of NADH and NAD⁺ at a Hybrid Lipid Bilayer Membrane Using Ubiquinone

作者：Ma, Wei[1,2];Li, Da-Wei[1,2];Sutherland, Todd C.[3];Li, Yang[1,2];Long, Yi-Tao[1,2];Chen, Hong-Yuan[4,5]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China;[3]Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada;[4]Nanjing Univ, Key Lab Analyt Chem Life Sci, Nanjing 210093, Peoples R China;[5]Nanjing Univ, Dept Chem, Nanjing 210093, Peoples R China

年份：2011

卷号：133

期号：32

起止页码：12366

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000294740000013)】；

基金：This research was supported by the Natural Science Foundation of China (Grant No. 91027035, 20933007), the Fundamental Research Funds for the Central Universities (Grant No. WK1013002) and the open research find from Key Laboratory of Analytical Chemistry for Life Science of Nanjing University. Y.T.L. is supported by The Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning.

语种：英文

摘要：Here, we report the reversible interconversion between NADH and NAD(+) at a low overpotential, which is in part mediated by ubiquinone embedded in a biomimetic membrane to mimic the initial stages of respiration. This system can be used as a platform to examine biologically relevant electroactive molecules embedded in a natural membrane environment and provide new insights into the mechanism of biological redox cycling.