文献类型：期刊文献

英文题名：Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies

作者：Liao, Liang[1,2];Wang, Qiang[1];Gao, Zhengyang[1];Liu, Jiayao[1];Tong, Yuxuan[1];Chen, Xin[1];Zhu, Jin[1];Li, Jian[1,3,4];Wei, Jinlian[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai Key Lab New Drug Design, Sch Pharm,State Key Lab Bioreactor Engn,Shanghai F, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Mat Med, Dept Technol Transfer, Shanghai 201203, Peoples R China;[3]Shihezi Univ, Sch Pharm, Key Lab Xinjiang Phytomedicine Resource & Utilizat, Minist Educ, Shihezi 832003, Peoples R China;[4]Hainan Univ, Coll Pharm, Key Lab Trop Biol Resources, Minist Educ, Haikou 570228, Peoples R China

年份：2026

卷号：16

期号：1

起止页码：647

外文期刊名：ACTA PHARMACEUTICA SINICA B

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001665387900001)】；

基金：This work was supported by the National Natural Science Foundation of China (22037002, 32121005) , Innovative Research Team of High-level Local Universities in Shanghai (SHSMU-ZDCX20212702, China) , National Special Fund for State Key Laboratory of Bioreactor Engineering (2060204, China) , and Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (2021 Sci & Tech 03-28, China) .r Team of High-level Local Universities in Shanghai (SHSMU-ZDCX20212702, China) , National Special Fund for State Key Laboratory of Bioreactor Engineering (2060204, China) , and Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (2021 Sci & Tech 03-28, China) .

语种：英文

外文关键词：CRBN; Fluorescence polarization; Rifamycin O; Novel ligand; Hematopoietic malignancies; IKZF1/3; Molecular glue; Proteasomal degradation