文献类型：期刊文献

英文题名：Co(OAc)2-Catalyzed Trifluoromethylation and C(3)-Selective Arylation of 2-(Propargylamino)pyridines via a 6-Endo-Dig Cyclization

作者：Li, Jianjun[1,2];Lei, Yifan[1,2];Yu, Yang[1,2];Qin, Cong[1,2];Fu, Yiwei[1,2];Li, Hao[1,2];Wang, Wei[1,2,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioengn Reactor, Shanghai Key Lab New Drug Design, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[3]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2017

卷号：19

期号：22

起止页码：6052

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000416204300006)，CCR-EXPANDED(收录号:WOS:000416204300006)】；

基金：Financial support of this research from the program for the National Science Foundation of China (21738002, 21372073, 21572054, and 21572055), the Fundamental Research Funds for the Central Universities is gratefully acknowledged.

语种：英文

摘要：A Co(OAc)(2)-catalyzed trifluoromethylation and subsequent C(3) -selective arylation of 2-(propargylamino)-pyridines has been developed. A new 6-endo-dig cyclization involving an unprecedented C(3) selective arylation of the pyridines instead of a commonly observed 5-exo-dig cyclization with "N" is realized. Moreover, the study presents the first case of the installation of a trifluoromethyl group into electron deficient azaarenes. The process delivers an efficient cascade approach to new trifluoromethylated 1,8-naphthyridine structures with a broad substrate scope.